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Direct effects of GLP-1 receptor agonism on the heart is likely not a major contributor

Both contained small protein molecules that broke down too quickly in the gut and weren't stable enough for development

Related: Oprah Winfrey Reveals Unexpected Effect of GLP-1 Medication on Her Health What About Over-The-Counter GLP-1 Patches

How to self inject GLP-1 or Tirzepatide medication (Subcutaneous Injection) Dosing and Step-by-Step Instructions Medication Specific Questions All medications should be refrigerated when they are received

The surge in popularity of medications that mimic its effects has sparked widespread curiosity

It appears that the only hope for prices going down is 1) Medicare negotiating a lower price directly with manufacturers in 2027 or 2) a successful patent challenge that results in generic manufacturing