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The CV safety of a lower dose of liraglutide (1.8 mg, Victoza, Novo Nordisk) in people with T2D was established in the Liraglutide Effect and Action in Diabetes: Evaluation of CV Outcome Results (LEADER) study, showing a 13% reduction in major CV events over an average of 3.8 years [44]

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Patients with certain GLP1R variants, for example, may benefit from earlier escalation to dual-compound therapy, while others optimize on semaglutide monotherapy

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