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The use of biomarkers for oxidative stress may provide further evidence of a causal relationship between oxidative damage to macromolecules (DNA, lipids, and proteins)

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Clinicians should also consider the increased risks of pancreatitis and sarcopenia, conditions that disproportionately affect people with SMIs

Furthermore, the enzyme is upregulated in several types of cancer, including malignant mesothelioma

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11.1 Animal studies Animal and in vivo studies have shown enhanced steroid responsiveness, lower airway hyperresponsiveness (AHR), and reduction in inflammatory cells and oxidative stress in asthma (150153)