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Glutathione supplementation does not alter tirzepatide pharmacokinetics, but NAC in high doses (above 1800mg daily) can affect cysteine-dependent metabolic pathways that influence insulin sensitivity, which may interact with tirzepatide's glucose-lowering effects in patients with type 2 diabetes

Pharmacotherapy and nutritional strategy should operate together not separately

Glutathione is a naturally occurring antioxidant that plays a critical role in protecting cells from oxidative stress and maintaining the immune system

Behavioral deficits were measured using stereotyped climbing, open field, forced swimming, and Y-maze tests, followed by sacrifice

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The current standard of care for acute ischemic stroke is recombinant tPA, which can open up large arteries but often does not do much for microvascular flow, which limits brain tissue repair