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De-identified whole blood from each time point was immediately divided in two 2-mL portions in EDTA-treated tubes and placed at 4C

A previous study reveals that under diabetic conditions, renal succinate accumulation has been recognized as a key metabolic disorder that not only impairs mitochondrial -oxidation but also exacerbates oxidative stress 28

This cold sensation is transmitted through the nervous system, which can divert or reduce the perception of pain signals