When treatment is discontinued, appetite returns, metabolic rate adjustments reverse, and weight regain begins
GLP-1 modulates actin polymerization, influencing insulin secretion
Quite often if you lose and gain weight quickly, the first place it stores is viscerally (within the abdominal cavity), over-flowing into the subcutaneous tissue
I do think there are more than a few long-term side effects that I'm interested in watching with regard to these drugs because in effect you're losing weight because your appetite's being suppressed
However, in the context of increased C-peptide levels, there are some other effects that are more relevant: Continuous infusion of GLP1 for 2 days, has been shown to be able to help prevent the death of beta cells in a rat-model of T2DM (Zucker Diabetic rats) (Farilla et al, 2002)
Start: Begin at 100 mcg once daily to gauge tolerability