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was applied (i.p.) simultaneously or 15 minutes before application of the convulsive agents (mg/kg b.w., i.p.) picrotoxine (3), strychnine (6, 3 or 1.5), bicuculline (2.5) and isoniazide (800 mg)

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Unlike apoptosis, which involves caspase activation and nuclear fragmentation, ferroptosis is initiated by iron accumulation and lipid peroxidation, resulting in membrane rupture without caspase involvement ( This review aims to comprehensively analyze recent advances in understanding ferroptosis mechanisms in CHD and evaluate emerging clinical intervention strategies

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