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Some studies suggest that antioxidants can alter the effectiveness of certain antibiotics by modulating oxidative stress levels

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10.1016/s0092-8674(00)81683-9 85 HaoF.KaleS.DimitrovS.HayesJ

In some embodiments, otic administration of the formulations or compositions described herein avoids toxicity associated with systemic administration (e.g., hepatotoxicity, cardiotoxicity, gastrointestinal side effects, and renal toxicity) of the active agents

This risk of muscle loss is why we focus on getting enough protein and incorporating resistance exercise during treatment to help maintain muscle mass while losing weight