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IL8 and tumor necrosis factor (TNF), markers of oxidative stress and inflammation, are also increasing (47)

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Consequently, NF-B is released and translocates to the nucleus where it transactivates multiple target genes strongly promoting inflammation [22,23]

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At the same time, iron-dependent lipoxygenase (LOX) catalyzes polyunsaturated fatty acids (PUFAs) to induce OS, which further alters the permeability of BBB (Figure 2)