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Beyond these major organs, the receptor turns up on cells of the immune system, including macrophages, lymphocytes, and invariant natural killer T cells, where it appears to exert anti-inflammatory effects

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Quad-agonists and even more complex multi-receptor compounds are already in preclinical development

Consequently, in the forthcoming period, it is imperative to conduct in-depth investigations into the specific molecular mechanisms underlying the anti-inflammatory and immunomodulatory properties of GLP-1RAs in psoriasis

As a negative control, we treated the HAP with only 100 nM cilostamide

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