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The higher dose tested was associated with a plasma exposure (Cave, ss) 8 or 4 times that in humans at the recommended human dose (RHD) for migraine (120 mg) or episodic cluster headache (300 mg), respectively

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OwJRCaldezMJZaferGFooJCLiHYGhoshSet alRemodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division

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The GIP component enhances insulin secretion when blood glucose is elevated and may also influence fat metabolism, though its exact contribution to weight loss in humans is still being studied