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Feedback inhibition by thiols outranks glutathione depletion: a luciferase-based screen reveals glutathione-deficient -ECS and glutathione synthetase mutants impaired in cadmium-induced sulfate assimilation

Promoting lipid utilization with L-carnitine to improve oocyte quality

Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro

T ransient nausea, diarrhea, and mild irritation at the injection site have been reported as adverse undesirable effects in preclinical studies

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Since GSH is a critical cofactor for GPX4, this depletion directly impairs GPX4 activity, rendering airway epithelial cells and alveolar macrophages highly susceptible to ferroptosis following oxidative insults such as CS exposure ( 2.1.2 System Xc- (SLC7A11) The cystine/glutamate antiporter System Xc- is a key regulator of cellular redox balance and antioxidant defense ( - reinforces cellular defenses against oxidative damage, making it a key target for modulating ferroptosis in COPD