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Moreover, the body weights of MTX and HPE-treated group recorded a highly significant increase ( p 0.001) at the fifth day compared with MTX-treated animals within the same period (5 days), but it was still showing a significant decrease at p 0.05 compared with the control animals

Accordingly, the role of sUA was confirmed using an in vitro assay in which we demonstrated that sUA stimulated the dose- and time-dependent production of inflammasome-related molecules in the presence of Nlrp3 and Myd88