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This results in most patients being diagnosed at advanced stages, contributing to the poor prognosis and low five-year survival rate, making it known as the king of cancer. For patients with resectable PC, early surgical intervention followed by adjuvant therapy remains the preferred approach, offering potential cure [267]

Accordingly, less susceptibility of alcohol and isoniazid was observed in CYP2E1-knockout mice in an ALI setting (Lee et al., 1996)

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We limited the scope of this study to patients with measured pH values 7.35, thereby excluding patients with fully respiratory compensated metabolic acidosis