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J Cardiovasc Dev Dis

Decision to Initiate GLP-1 Therapy Richards endocrinologist is considering adding a GLP-1 receptor agonist to improve glycemic control and reduce weight

GLP-1s also reduce the rate at which the stomach digests food and empties, reducing appetite and make you feel fuller longer

Moreover, it is increasingly recognized that weight loss itself primarily serves as a surrogate marker for favorable changes in body fat distribution, particularly reductions in ectopic fat depots such as visceral adipose tissue and intrahepatic lipid content, both of which are strongly associated with ASCVD risk (80, 81)

This suggests that trevogrumab alone, without garetosmab, may offer a more viable safety profile for clinical practice

women of childbearing potential should use effective contraception, and semaglutide should be discontinued at least 2 months before a planned pregnancy Drug interactions : Tirzepatide may reduce oral contraceptive exposure during dose escalation