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Transcriptome analysis has revealed that estrogen plays a pivotal role in regulating the very genes involved in lipid metabolism that GLP-1 receptor agonists also target [2]

The authors anticipated that during stages of development and aging, these genes would converge into distinct coexpression pathways in specific brain regions

J Biol Chem [Internet]

Its especially helpful when combined with other peptides like CJC-1295, but more on that later

2020;192:E875E891

The practical impact of metabolic withdrawal: large-scale population studies suggest that individuals who use and then discontinue GLP-1RAs before pregnancy may experience excessive gestational weight gain (GWG) and an increased risk of gestational diabetes mellitus (GDM) and gestational hypertension (137)