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This has guided clinicians in anticipating the risk for malignancy and management options (Table 7-1)

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GHK-Cu and Gene Expression Research Research using the Broad Institutes Connectivity Map found that GHK is capable of up- and downregulating at least 4,000 human genes, with studies identifying 47 DNA repair genes stimulated and 5 suppressed findings that suggest a broad regulatory role at the genomic level

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Combined with secretory factors (SASP) from senescent cells induced locally by mitochondrial damage or endoplasmic reticulum stress, these elements collectively establish a pro-proliferative, anti-apoptotic inflammatory microenvironment