10.1056/NEJM199205143262003
2), these cytokines set in motion a vicious cycle of inflammation, as supported by recent studies highlighting the involvement of IL-17, IL-23, and NF-B in PsO pathogenesis [18,19,20]
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d Chronic kidney disease is defined by an eGFR of 60 mL/min/1.73 m 2 or lower
There may be options such as staying at a lower dose for longer, delaying a step-up, reviewing other medicines, or considering an alternative treatment
Generating sufficient safety evidence would require large-scale clinical trials involving thousands of participants