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However, the findings underscore the need for individualized risk benefit assessments when prescribing GLP-1 RAs such as semaglutide in frail populations, considering factors such as tolerability, route of administration, and the overarching goals of therapy in older adults with limited physiological reserve

doi: 10.1016/j.ejphar.2018.01.037 54 MatthysPHatseSVermeireKWuytsABridgerGHensonGWet al