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Like tirzepatide, it works through incretin pathways, meaning it occupies different receptor territory than cagrilintide

FIGURE 1 Increased permeability of the IEB and dysbacteriosis is considered to be strongly correlated

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Notably, HZRG specifically increased the enrichment of Lactobacillaceae , Bifidobacteriaceae , Clostruduaceae , Chostridiales VadinBB60 , Corynebacteriaceae , Solanales , Propionibacteriaceae , Micrococcaceae , and Satphylococcaceae (Figure 3E)

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Mice were anesthetized by inhaling a mixture of 1 L/min oxygen and 1%1.5% isoflurane via a mask, while maintaining normal respiration