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During pregnancy, your immune system is lowered since youre sharing it with a growing fetus, says Dara Godfrey, MS, RD, registered dietician for Reproductive Medicine Associates of New York

Ultimately, four studies were included

The forward-looking statements contained in this communication are made only as of April 23, 2026

Key Insights Fatigue is a common but usually temporary side effect during the initial weeks or dose changes in GLP-1 therapy, caused largely by rapid calorie deficit, dehydration, and metabolic adjustments. Maintaining steady energy requires prioritising nutrient-dense meals rich in protein and complex carbohydrates, staying well hydrated, and managing electrolyte balance, which helps mitigate tiredness and supports overall metabolism. Gentle physical activity and good sleep hygiene are critical lifestyle adjustments that improve circulation, mood, and energy levels without overtaxing the body during the drug adaptation period. Persistent, worsening, or debilitating fatigue should prompt medical evaluation to exclude other causes, reassess medication dosing, and ensure safe continuation of GLP-1 therapy under healthcare supervision. Frequently asked questions Why do GLP-1 medications cause fatigue

When speaking with your provider, specifically ask if they work exclusively with sterile compounding pharmacies

Talk to your doctor and diabetes care team if you have type 2 diabetes and want to see if GLP-1s fit your health goals