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We do not know the optimal human dosing, long-term safety profile in humans, or whether animal results translate directly to human outcomes

Both amide bond-forming enzymes display notable biocatalytic potential, including scalability, stereoselectivity toward the warhead and broader substrate scopes in forming the amide bonds

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The impact of GEP12 on food intake relative to baseline was notably less than that observed in response to GEP44 (at 5 nmol/kg/day: mean difference 36.5%, 95% CI 14.9% to 58.0%, p = 0.0009