This underscores the need for both RWE and RCTs in parallel and reinforces the need to need to run clinical trials that reflect real-world populations, a topic explored in more detail in our blog Obesity trials on trial Some health improvement seen with GLP-1 therapy may be a direct effect of weight loss, rather than unique drug effect as seen by improvements in liver and kidney health 4
Community sources and trialists commonly describe lean-mass loss as a general concern across the incretin-agonist class, which is part of why an explicitly muscle-preserving mechanism is the angle the bioglutide data has emphasized
"BPC-157 is not an NHP," he said
Effects on Muscle Mass Muscle mass plays a critical role in glucose management, as well as in the prevention and management of diabetes and other metabolic conditions
For a deeper dive into the molecule itself, see What is Glutathione and Why It Matters for Our Health
including a prior authorization protocol that requires chart documentation of a type 2 diabetes diagnosis based on a recent A1C (measurement of average blood sugar levels) equal to or greater than 6.5%
