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Under normal conditions, Nrf2 is anchored in the cytosol through its interaction with Kelch-like ECH-associated protein 1 (Keap1), which serves as a substrate adapter protein for an E3 ubiquitin ligase complex (Zhang et al
Potos and its silver mines
Chronic inflammation can Reduce flexibility of vein wall Cause malfunctioning of vein valve Reduce oxygen and nutrient supply to tissues Cause pain and swelling Increase the risk of blood clots All of these factors can contribute to varicose veins which can again lead to chronic inflammation
