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There is limited research on the head-to-head comparison of cardioprotective effects of GLP-1RAs and SGLT2 inhibitors, and the reason(s) for the similarity in the cardioprotective effect of these drug classes is not fully understood

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As such, maintaining the bodys ability to produce and use insulin effectively may have major implications for Parkinsons in addition to diabetes

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Data availability All data needed to understand and assess the conclusions of this research are available in the main text, supplementary materials, the Disease-PERCEPTION portal ( and The raw gene expression datasets are publicly available and can be downloaded from GEO and ArrayExpress ( The identifiers for each of the studies are provided in Supplementary Data 1