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The actin-binding domain (Ac-LKKTETQ)the active core of TB-500has accelerated wound closure in aged and diabetic mouse models by enhancing keratinocyte migration, collagen deposition, and reducing scarring [10]

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The review also noted that GHK-Cus copper complexation ability raises Cu2+ penetration rates across the stratum corneum, and documented the development of formulation innovations including the TriHex peptide system that combine GHK-Cu-type tripeptides with hexapeptides to produce synergistic upregulation of regenerative genes and suppression of aberrant collagen deposition

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Skin tone becomes more even as collagen types I and III accumulate in the dermis