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Additionally, loss of muscle mass during rapid weight loss can reduce the efficiency of muscle pumps that help return blood from the extremities to the heart, leading to blood stasis, particularly in the legs, which is a risk factor for deep vein thrombosis (DVT)

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Matthews et al., 2019

Glucocorticoid Signaling The metabolic processing and transportation of glutamine face disruption from glucocorticoids which include cortisol