gRNA-mediated Cas9 double-strand break of genomic DNA between codons tyrosine-972 and leucine-973 should initiate homologous-directed repair using the ssDNA repair oligo, thereby mutating the PAM sequence, exchanging codon leucine-973 to phenylalanine-973, as well as inserting silent point mutations at codons glycine-962 and proline-963 to generate an ApaI restriction site for genotyping
If heartburn persists beyond 8 weeks or worsens despite lifestyle changes, contact your PlexusDx provider to evaluate whether a slower dosing schedule or pharmaceutical intervention is appropriate for your situation
Consider: Reduced red meat intake Reduced protein intake Reduced whole grains Reduced vegetable intake Reduced fat intake If YES Intake-related micronutrient risk increases If NO Risk remains lower Step 4: Are Symptoms Present
Alderson, T
Your prescribing physician will determine your specific dose based on your individual health needs
GLP-1 medications require careful titration, proactive side effect management, and ongoing monitoringcharacteristics that make them unsuitable for what some physicians describe as prescription and wave models where follow-up is minimal
