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Managing weight is harder than most advice admits

Clinical trials of injectable tirzepatide show dramatic weight loss (on average 1520% in 68-week trials)

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doi:10.1089/acm.2012.0612 [10] Costantini A, Nappo A, Pala MI, Zappone A

Step therapy: 63% require members to try lower-cost medications first

Comparing semaglutide with seven other antidiabetic medications, they emulated seven target trials with a total of 1,094,761 eligible subjects who had been diagnosed with type 2 diabetes and who had no prior Alzheimers disease diagnosis