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MC1R agonism triggers tyrosinase, tyrosinase converts tyrosine to melanin, and UV accelerates the reaction

It follows a set 16-week dose escalation: Weeks 14: 0.25 mg Weeks 58: 0.5 mg Weeks 912: 1 mg Weeks 1316: 1.7 mg From Week 17 onward: Maintenance dose of 2.4 mg This gradual increase is designed to reduce side effects while optimizing the medications weight loss benefits