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Considering only events within various age groups, the ICERs indicated that SGLT2is were not cost-effective for people aged 1039 years or 4059 years for any intervention (although the ICER for SGLT2is in the secondary prevention population was 29,420), while SGLT2is were cost-effective among people aged 6079 years (ICERs of 28,002 and 328 in the primary prevention and secondary prevention populations, respectively) and 80 years, but GLP-1 RAs were not

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patients frequently report feeling a highly pleasant, immediate 'wellness boost' and physical energy surge

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Rare effects ( = 2% of patients

Moreover, SCFAs produced in the gut not only achieve systemic distribution but also serve as an energy source and act as signaling molecules (74)