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Because nicotinamide would otherwise re-enter the NAD+ salvage pathway through NAMPT and NMN, NNMT activity sits at a junction between cellular methylation capacity and NAD+ regeneration, which is why the enzyme became a target after Kraus and colleagues (Nature, 2014) reported the consequences of antisense Nnmt knockdown in white adipose tissue and liver

These include: Warning icon- Picture Courtesy: istockphoto.com Although, Vitamin B is overall nontoxic, however, its overuse may cause dangerous side effects such as heartburn, nausea, and allergic reaction

Many drugs used to treat obesity in the past have been discontinued because of their potential to be abused and their toxicities [20-27] (Table 1 )

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