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Mitochondrial dysfunction in HD includes impaired electron transport chain activity, reduced mitochondrial biogenesis, and defective mitophagy, all of which contribute to increased oxidative stress and neuronal damage [165]
GLP-1 receptors exist throughout the hypothalamus and brainstem, specifically in areas that control appetite and food reward
Its well understood that the drugs act directly on the cells in the pancreas and the brain, where GLP-1 receptors are plentiful, to regulate blood glucose and control appetite
Eating slowly and chewing thoroughly also signals fullness earlier, aligning with semaglutide's natural effect
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