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At 0.2mmol/l CuSO 4 , no significant differences were observed, but higher concentrations (0.41.4.2mmol/l) significantly increased toxicity in HepG2 ATP7B-KO cells (Fig

These effects were linked to the activation of signaling pathways such as FAK-paxillin, suggesting a role in regulating cellular movement and structural organization in experimental systems

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Further mechanistic studies revealed the key role of SAC in regulating the Keap1/Nrf2/GPX4 signaling pathway

Composition & Specifications The formulation contains two components: Sterile Purified Water Purified, sterile, non-pyrogenic water meeting USP compendial specifications for sterile purified water

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