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Although current guidlines mainly recommend SGLT-2 inhibitors and GLP-1 RAs to be served as first-line drugs to T2DM patients with high cardiovascular risks due to their proven cardiovascular benefits, effects of metformin on MACE still remain potential and dubious according to ADA 2023

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GCG-induced GSIS was significantly reduced in Gcgr / mouse islets, whereas GLP-1-, GIP- and triagonist-induced insulin secretion remained comparable with insulin secretion in WT mice (Fig

Oxidative Stress and Behavior Elevated copper and low zinc can shift the brains chemistry toward excessive stimulation

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Zaffagnini et al., 2012a