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An exception is topical administration, which generally means that both the application location and the effect thereof is local

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In mouse models of highfat dietinduced liver steatosis, it significantly inhibits hepatic NNMT activity, reduces NAM methylation, increases NAD+ and SAM levels, enhances mitochondrial fatty acid oxidation, reduces hepatic triglyceride and lipid accumulation, lowers lipotoxicity markers (e.g., malondialdehyde, transaminases), improves hepatocellular injury, and reverses steatosis

Indian Journal of Endocrinology and Metabolism (2024) 10

Immune and inflammatory mechanisms in neuropathic pain