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Manganese induces tumor cell ferroptosis through type-I IFN dependent inhibition of mitochondrial dihydroorotate dehydrogenase

110 MaQ.CaiM.ShangJ.-W.YangJ.GuX.-Y.LiuW.-B.et al (2016)

The STEP 5 trial extended this data, showing sustained weight loss of 15.2 percent over 104 weeks

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For example, older adults or individuals with metabolic dysregulation may exhibit a blunted IGF-1 response compared to younger, healthier individuals (39)