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Kesarwani, K., & Gupta, R

In the ALS rodent model, the mitochondrial biogenesis regulator PGC-1 has been demonstrated to protect upper motor neurons, participate in the production of neuromuscular junctions in lower motor neurons, and regulate oxidative stress in sensory neurons (Kuczynska et al., 2021)

Six normal subjects injected with 25 nmol/kg DSIP once in the morning showed a significant increase in total sleep for the next 2 hours (median increase of 59%)

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However, some stem cell populations share surface markers and signaling features with senescent cells, raising a theoretical concern about off-target effects on tissue-resident stem cells