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The most-affected pathways include antioxidant defense, DNA repair, ubiquitin-proteasome activity, and TGF-beta signaling

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10,11,12 However, as negatively charged biological macromolecules, NADs have difficulty in crossing cellular membranes to enter cells

Their action signals the cell to modulate its response, through the recruitment of endogenous coping mechanisms, among which are an increased synthesis of antioxidants and of electrophile quenchers, the transcription of the necessary gene products and the production of reducing cofactors such as NADH/NADPH and ascorbate

doi:10.1186/s12944-018-0779-4

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