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This study investigated whether cerebral GSH or GABA levels differ between a large cohort of children aged 8-12 years with ASD (n=52) and typically developing children (TDC, n=49)

While mTORC1/S6K1 hyperactivation is the most extensively characterized node, the pathological consequences of impaired BCAA catabolism involve at least three additional parallel mechanisms that operate independently of mTORC1

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Conversely, the expression of AKT3, an isoform of AKT known for its oncogenic and anti-apoptotic functions 51 , was found to be diminished following the treatment of cancer cells with pDNA/Polybia-MP1