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This is distinct from the appetite-suppressing effect of GLP-1 and GIP

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There are some mechanisms by which tesofensine may contribute to increased fat burning such as increased metabolism, appetite suppression, and modulation of neurotransmitters

If gastrointestinal symptoms significantly impair quality of life or prevent medication adherence despite conservative management, healthcare providers may consider dose adjustment, alternative agents with potentially different side effect profiles, or referral to a gastroenterologist for specialized evaluation