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Adolescents with T1D could benefit from this class of drugs because they tend to have insulin resistance and live with overweight or obesity, and those who develop T1D earlier in life have a greater lifetime risk of long-term complications
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Obes Surg 31(4):17551766 Nedelcu M, Khwaja HA, Rogula TG (2016) Weight regain after bariatric surgery-how should it be defined
Systemically, compared with healthy individuals, individuals with insulin resistance have elevated plasma insulin levels, elevated plasma glucose levels and impaired glucose clearance in response to the same bolus of insulin
Most notably, the highest dose of retatrutide (12 mg) led to 24.2% weight loss (vs 2.1% with placebo) at 48 weeks