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However, due to their procedural complexity and high costs, these modalities are currently primarily utilized for mechanistic studies and have not been adopted for routine clinical evaluation (95) (Figure 1)

289 87358741 10.1074/jbc.R113.544635 [DOI] [PMC free article] [PubMed] [Google Scholar] Sileikyte J., Blachly-Dyson E., Sewell R., Carpi A., Menabo R., Di Lisa F., et al

These include having had one previous episode of DKA, high HbA 1c , low self-management skills (including omission of insulin therapy), psychiatric disorders, infections, somatic comorbidity, alcohol and drug abuse and less interaction with the healthcare team [211,212,213]

In contrast, no significant enrichment of genes involved in the mTOR signaling pathway was detected (Figure 3A)