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[DOI] [PMC free article] [PubMed] [Google Scholar] 190.Kim M., Seol J., Sato T., Fukamizu Y., Sakurai T., Okura T

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[70] found in vivo and in vitro studies that GLP-1 and its analog exendin-4 were able to induce an increase in ABCA1 mRNA, increase the expression of apo AI mRNA and promoter, thereby increasing apo AI secretion, indicating that GLP-1 in hepatocytes may mediate the outflow of intracellular cholesterol to apo AI through the ABCA1 pathway

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These steps help GLP-1 therapy work better and reduce problems like tiredness

The company also confirmed plans to lower prices for its injectable drugs, including Wegovy and Ozempic, under Medicare Part D, Medicaid and self-pay channels