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One unexpected serious adverse reaction occurred in a NAC-treated patient caused by an erroneous iv infusion rate (1.5g-loading dose-15 min followed by 7.5 g delivered over 3h15min instead of 4 h), causing chest tightness, despite stable vital signs, which was resolved by corticosteroids and discontinuation of iv NAC

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The STEP 1 extension study followed participants who discontinued treatment after 68 weeks

PMID: 37057810 Life Sci Alliance HCV poly U/UC sequence-induced inflammation leads to metabolic disorders in vulvar lichen sclerosis