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Rising GLP-1 spend, escalating health costs, and billions in lost productivity

Data extraction and risk of bias assessment Two researchers extracted data including the characteristics of the study population (number of patients per group, age, sex, diabetic status, liver disease status [NAFLD or NASH], and BMI per group), intervention(s) (TZD or GLP-1RA, treatment duration), control(s), outcome(s), and study results for each outcome according to a predefined Excel format

The next most common abnormality is maternal disomy 15, found in around 35% of cases, and a defect in the imprinting center that controls the activity of certain genes on chromosome 15, seen in 1-3% of cases

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doi:10.1210/jcem-70-4-975 Laferrre B, Abraham C, Russell CD, Bowers CY

Similarly, D 2 R was unable to mediate the nuclear accumulation of Garrestin3 (Additional file 1: Fig