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M.Zarco-MrquezG.Molina-JijnE.Cristbal-GarcaM.et al (2012)

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Studies show both of ES and cannabinoid receptor type 1 (CB1) are associated with oxidative/nitrosative stress and may also play a role in modulating liver inflammation, ultimately promoting disease progression toward steatohepatitis

Prog Lipid Res 49:6175

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This makes the estrogen even easier to remove from the body, making it safe to be excreted