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In Phase 2 trials published in the *New England Journal of Medicine* (2023), participants lost an average of 17.5% of body weight at the highest dose over 24 weeks outperforming tirzepatide and semaglutide in head-to-head data comparisons

Scand J Gastroenterol 31: 665-670, 1996

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The plateaus were temporary

doi: 10.1038/s41564-021-00880-5

Since GLP-1 medications mimic the action of a peptide produced in the GI tract, most reported mild side effects are associated with the digestive tract