McGraw-Hill / Lange rxlist.com (Glyset ) Keywords DPP-4 Inhibitors Sitagliptin Trade Name: Januvia Drug Class: oral hypoglycemics Mechanism of Action: An inhibitor of dipeptidyl peptidase-4 (DPP-4), a protease that degrades the incretin GLP-1 Incretins are hormones released from the GI tract in response to nutrient ingestion Incretins potentiate glucose-stimulated insulin secretion from beta cells in the pancreas As a result of inhibiting DPP-4, increased or prolonged GLP-1 levels are able to potentiate the secretion of insulin by the pancreas The effect produced by DPP-4 inhibitors is dependent on endogenous GLP-1 levels, and produce a modest effect on GLP-1 activity compared to giving GLP-1 receptor agonists (hence DPP-4 inhibitors do not have the same impact to produce weight loss as GLP-1 agonists)
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However, contrasting Qsymia vs Wegovy or Qsymia vs Zepbound shows that GLP-1 medications offer a different mechanism of action, focusing on hormonal regulation of metabolism rather than just appetite suppression
Look for liposomal formats to ensure the glutathione survives the "stomach acid gauntlet." If you are taking a supplement that is just raw powder in a capsule, you may not be getting the value you expect
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