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Progressive Dosing Schedule and Weight Loss Timeline After the initial 0.25 mg phase, doses increase by 0.25 mg increments every 4 weeks: 0.25 mg (weeks 14), 0.5 mg (weeks 58), 0.75 mg (weeks 912), and 1.0 mg (weeks 1316)

PMID: 150 BevilacquaADragottoJGiulianiABizzarriM

Most of the patients were male (N=24, 60%)

Niacinamide-specific side effects At the low doses used in compounded formulations (2 mg per mL), niacinamide side effects are extremely unlikely

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The results indicated a high degree of affinity and binding between GLP-1 and LRP5, thereby providing a theoretical foundation for the subsequent experimental procedures (Supplementary Figure S1)